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vivo mab anti mouse cd8α antibody  (Bio X Cell)


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    Bio X Cell vivo mab anti mouse cd8α antibody
    Vivo Mab Anti Mouse Cd8α Antibody, supplied by Bio X Cell, used in various techniques. Bioz Stars score: 96/100, based on 202 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/vivo+monoclonal+antibody/pm41735281-205-1-8?v=Bio+X+Cell
    Average 96 stars, based on 202 article reviews
    vivo mab anti mouse cd8α antibody - by Bioz Stars, 2026-07
    96/100 stars

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    PH induces pyroptosis to <t>potentiate</t> <t>PD-1</t> blockade (A) Representative immunofluorescence images of CD8 and GZMB staining in YUMM1.7 P - and YUMM1.7 DTR -derived tumors; right: quantification of indicated staining-positive cells. Scale bars, 10 μm. (B–D) YUMM1.7 DTR cells stably expressing the indicated shRNAs were subcutaneously injected into immunocompetent C57BL/6J mice. When tumor sizes reached 50 mm 3 (day 5, labeled as day 0 in C), mice were administrated with the indicated drugs (B). Tumor size in each group was recorded every 3 days (C). At the endpoint, the tumors were excised and weighed (D). PH, 25 mg/kg, intraperitoneal (i.p.) injection, daily. IgG2a or anti-PD-1 was diluted in saline and then given i.p. every 3 days. n = 7 tumors per group. (E) CD8 and GZMB staining in YUMM1.7 DTR allografts with the indicated treatment (left). Right: quantification of the indicated staining-positive cells. Scale bars, 10 μm. (F) Frequencies of intratumoral CD3ε + (left), CD4 + (middle), and CD8 + (right) cells among CD45 + cells. n = 7 tumors per group. (G) Frequencies of intratumoral GZMB + (left), PRF1 + (middle), and IFN-γ + (right) cells among CD8 + T cells. n = 7 tumors per group. Data are displayed as mean ± SEM. Statistical significance was determined by Student’s t test. ∗∗∗ p < 0.001, ∗∗ p < 0.01, ∗ p < 0.05, n.s., not significant. See also , , and .
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    Image Search Results


    PH induces pyroptosis to potentiate PD-1 blockade (A) Representative immunofluorescence images of CD8 and GZMB staining in YUMM1.7 P - and YUMM1.7 DTR -derived tumors; right: quantification of indicated staining-positive cells. Scale bars, 10 μm. (B–D) YUMM1.7 DTR cells stably expressing the indicated shRNAs were subcutaneously injected into immunocompetent C57BL/6J mice. When tumor sizes reached 50 mm 3 (day 5, labeled as day 0 in C), mice were administrated with the indicated drugs (B). Tumor size in each group was recorded every 3 days (C). At the endpoint, the tumors were excised and weighed (D). PH, 25 mg/kg, intraperitoneal (i.p.) injection, daily. IgG2a or anti-PD-1 was diluted in saline and then given i.p. every 3 days. n = 7 tumors per group. (E) CD8 and GZMB staining in YUMM1.7 DTR allografts with the indicated treatment (left). Right: quantification of the indicated staining-positive cells. Scale bars, 10 μm. (F) Frequencies of intratumoral CD3ε + (left), CD4 + (middle), and CD8 + (right) cells among CD45 + cells. n = 7 tumors per group. (G) Frequencies of intratumoral GZMB + (left), PRF1 + (middle), and IFN-γ + (right) cells among CD8 + T cells. n = 7 tumors per group. Data are displayed as mean ± SEM. Statistical significance was determined by Student’s t test. ∗∗∗ p < 0.001, ∗∗ p < 0.01, ∗ p < 0.05, n.s., not significant. See also , , and .

    Journal: Cell Reports Medicine

    Article Title: 5-HT reuptake blockade induces pyroptosis in BRAF V600E -mutated melanomas via remodeling histone serotonylation

    doi: 10.1016/j.xcrm.2025.102537

    Figure Lengend Snippet: PH induces pyroptosis to potentiate PD-1 blockade (A) Representative immunofluorescence images of CD8 and GZMB staining in YUMM1.7 P - and YUMM1.7 DTR -derived tumors; right: quantification of indicated staining-positive cells. Scale bars, 10 μm. (B–D) YUMM1.7 DTR cells stably expressing the indicated shRNAs were subcutaneously injected into immunocompetent C57BL/6J mice. When tumor sizes reached 50 mm 3 (day 5, labeled as day 0 in C), mice were administrated with the indicated drugs (B). Tumor size in each group was recorded every 3 days (C). At the endpoint, the tumors were excised and weighed (D). PH, 25 mg/kg, intraperitoneal (i.p.) injection, daily. IgG2a or anti-PD-1 was diluted in saline and then given i.p. every 3 days. n = 7 tumors per group. (E) CD8 and GZMB staining in YUMM1.7 DTR allografts with the indicated treatment (left). Right: quantification of the indicated staining-positive cells. Scale bars, 10 μm. (F) Frequencies of intratumoral CD3ε + (left), CD4 + (middle), and CD8 + (right) cells among CD45 + cells. n = 7 tumors per group. (G) Frequencies of intratumoral GZMB + (left), PRF1 + (middle), and IFN-γ + (right) cells among CD8 + T cells. n = 7 tumors per group. Data are displayed as mean ± SEM. Statistical significance was determined by Student’s t test. ∗∗∗ p < 0.001, ∗∗ p < 0.01, ∗ p < 0.05, n.s., not significant. See also , , and .

    Article Snippet: In vivo monoclonal anti-mouse PD-1 (CD279) (clone RMP1-14) , BioXcell , Cat# BE0146; RRID: AB_10949053.

    Techniques: Immunofluorescence, Staining, Derivative Assay, Stable Transfection, Expressing, Injection, Labeling, Saline